Glomerular Effects of Age and APOL1

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چکیده

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منابع مشابه

Glomerular Effects of Age and APOL1.

Two articles in this issue of JASN seek to identify structural weaknesses that render glomeruli liable to failure. Hodgin et al.1 examine glomerular loss with aging and propose that a gradual reduction in the number of podocytes per unit glomerular volume reaches a point where it triggers glomerular failure. As glomeruli are lost, compensatory hypertrophy of those that remain leads to additiona...

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Knockdown of ApoL1 in Zebrafish Larvae Affects the Glomerular Filtration Barrier and the Expression of Nephrin

APOL1, a secreted high-density lipoprotein, is expressed in different human tissues. Genetic variants of APOL1 are described to be associated with the development of end stage renal diseases in African Americans. In human kidney, APOL1 is mainly expressed in podocytes that are responsible for proper blood filtration. Since mice do not express ApoL1, the zebrafish is an ideal model to study the ...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2015

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.2015040459